Deepcell debuts AI-powered single cell analysis platform to boost cell biology, morpholomics discovery - The EE

Deepcell debuts AI-powered single cell analysis platform to boost cell biology, morpholomics discovery

Menlo Park, United States – Deepcell, a provider in artificial intelligence (AI)-powered single cell analysis to fuel deep biological discoveries, has announced the launch of REM-I Platform, a high-dimensional cell morphology analysis and sorting platform which comprises the REM-I benchtop instrument, human foundation model, and Axon data suite.

By bringing together single cell imaging, sorting, and high-dimensional analysis, the REM-I Platform will catalyse new methods of discovery in a wide range of fields including cancer biology, developmental biology, stem cell biology, gene therapy and functional screening, among others. Deepcell’s management team will present data on the company’s AI-based morphology profiling solutions, which leverage the company’s proprietary deep learning and computer vision model, during three scientific podium presentations at CYTO 2023 in Montreal, Quebec, May 20-24, 2023.

“Deepcell’s approach to bringing artificial intelligence into cellular analysis will revolutionise biological research, ushering in a new era of discovery,” says Maddison Masaeli, PhD, co-founder and chief executive officer at Deepcell. “We empower our customers to rapidly transform biological research by applying the latest advances in AI to morphology, which is the bedrock of cell biology.”

Cell morphology was one of the initial ways cells were studied since the advent of the microscope. Despite recent advancements in microscopy and flow cytometry, existing tools for cellular quantification and characterisation have left the field of cell biology hypothesis bounded and reliant on human interpretation, until now. With the new generation of AI and machine learning models like Deepcell’s human foundation model, cell morphology can finally join other high-dimensional, single cell analysis methods and enable researchers to realise the full potential of the morpholome.

“In the launch of the REM-I Platform we are witnessing the realisation of years of first-principle thinking about the future of cell biology—a future liberated from the constraints of prior knowledge,” says Euan Ashley, MD, PhD, scientific co-founder of Deepcell, associate dean in the Stanford University School of Medicine and professor at Stanford University. “With the help of sophisticated artificial intelligence models, we can surpass the limits of what our eyes can see and peer ever more deeply into the biology of individual cells. I can’t wait to see what the scientific community does with this powerful new tool.”

REM-I Platform enables unbounded single cell discovery and analysis

Deepcell technology has been used to capture and characterise more than two billion images of single cells across a large variety of cell types. The human foundation model, a self-supervised deep learning model trained on a subset of these unlabeled cellular images from a range of carefully selected biological samples, characterises brightfield single cell images captured on the REM-I instrument and generates high-dimensional embedding data. Researchers can use the Axon data suite to access, visualise, and analyse these data in real-time and perform sorting of their cell groups of interest into up to six outlets on the REM-I instrument.

“Until now, the field of morphology has been limited to human interpretation of cellular features. Advancing morphology-powered discovery requires a new way of thinking to scale up and democratise single cell data generation and to enable unprecedented insights,” says Mahyar Salek, PhD, co-founder, president, and chief technology officer at Deepcell. “Advances in machine learning will transform our understanding of cell phenotype akin to the way next-generation sequencing transformed our understanding of the genome.”

Deepcell launched its Technology Access Programme with the Translational Genomics Research Institute as well as University of California San Francisco, which leveraged the technology to study human cell lines, bodily fluids and solid tissues as part of cancer research and drug screening projects.

The company recently completed its initial European installation of the Deepcell technology through its Technology Access Programme at the Erasmus Medical Center in Rotterdam, which will use the instrument to study immune therapies from cancer patient samples.

“The Deepcell platform gives us the ability to discriminate between activated and naive T cells and provides next-level detection of therapy response in peripheral blood mononuclear cells derived from patients treated with immune therapies for cancer,” says Peter van der Spek, professor, department of pathology and clinical bioinformatics, Erasmus Medical Center. “Pathologists can increase the throughput of samples and assess many more cells than by conventional light microscopy.”

The REM-I Platform is available for orders and expected to begin shipping to customers in early 2024. For more information visit, Deepcell.

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